Pretreatment Lung Function and Checkpoint Inhibitor Pneumonitis in NSCLC.

ABSTRACT:

Introduction

Checkpoint inhibitor pneumonitis (CIP) is a serious toxicity of anti-programmed death-(ligand) 1 immunotherapy. Whether pretreatment differences in pulmonary function exist in patients who develop CIP is unknown. We analyzed the pulmonary function tests (PFTs) of patients with NSCLC treated with immune checkpoint inhibitors (ICIs) to evaluate whether pretreatment lung function was associated with CIP development.

Methods

Patients were included if they completed greater than or equal to 1 PFT within 2 years preceding ICI initiation. CIP status (CIP+: developed CIP, CIP-: did not develop CIP) was determined clinically. Generalized estimating equation-based linear regression was used to evaluate the effects of time and CIP on lung function. Primary outcomes include

SUBMITTER: Reuss JE 

PROVIDER: S-EPMC8552105 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature