Implications of Guideline-based, Risk-stratified Restaging Transurethral Resection of High-grade Ta Urothelial Carcinoma on Bacillus Calmette-Guerin Therapy Outcomes.

ABSTRACT:

Background

Guideline indications for restaging transurethral resection (reTUR) for high-grade (HG) Ta bladder tumors vary due to a paucity of data.

Objective

To investigate guideline-based, risk-adapted approaches to reTUR for HG Ta lesions.

Design, setting, and participants

An institutional review of HG Ta patients who received adequate bacillus Calmette-Guérin (BCG) from 2000 to 2019 was conducted.

Outcome measurements and statistical analysis

Guideline criteria for reTUR were used to stratify patients. Kaplan-Meier product limits estimated survival. Cox regression and log-rank tests identified association of variables with survival.

Results and limitations

Of the 209 patients with HG Ta bladder cancer, 104 (50%) underwent reTUR, which identified resid

SUBMITTER: Hensley PJ 

PROVIDER: S-EPMC8553807 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature