The protective impact of education on brain structure and function in Alzheimer's disease.

ABSTRACT:

Background

The Cognitive Reserve (CR) theory posits that brains with higher reserve can cope with more cerebral damage to minimize clinical manifestations. The aim of this study was to examine the effect of education (CR proxy) on brain structure and function in Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) patients and in cognitively healthy elderly (HC) individuals.

Methods

Fifty-seven AD patients, 57 aMCI patients and 48 HCs were included to investigate the relationships between education years and gray matter volume (GMV), regional homogeneity (ReHo) and functional connectivity (FC) in brain regions to show associations with both structure and function. Taking the severity of the disease into account, we further assessed the relationships in AD s

SUBMITTER: Zhu W 

PROVIDER: S-EPMC8557004 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature