Risk factors for development of nephropathy in patients with a diabetic Charcot foot.
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ABSTRACT: Objective
Charcot foot is a rare complication to neuropathy and can cause severe foot deformities and ulcerations, which often require prolonged antibiotical treatment. The objective of this retrospective study was to investigate whether this treatment is associated to impaired renal function.Results
In total, 163 patients were included, of whom 105 (64%) had received β-lactam antibiotics for a mean total duration of 13.0 months. There was a significant increase in the urine albumin/creatinine ratio in the group that received antibiotics (p = 0.017), and the use of antibiotics was associated to a subsequent diagnosis of nephropathy (p = 0.01). Patients treated with antibiotics had a 21.9% risk of developing subsequent nephropathy versus 5.2% for patients not treated with antibiotics. We suggest increased awareness on signs of nephropathy in patients with severe Charcot foot.
SUBMITTER: Jansen RB
PROVIDER: S-EPMC8557477 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Risk factors for development of nephropathy in patients with a diabetic Charcot foot.
Jansen Rasmus Bo RB Holstein Per E PE Jørgensen Bo B Møller Klaus Kirketerp KK Svendsen Ole Lander OL
BMC research notes 20211030 1
<h4>Objective</h4>Charcot foot is a rare complication to neuropathy and can cause severe foot deformities and ulcerations, which often require prolonged antibiotical treatment. The objective of this retrospective study was to investigate whether this treatment is associated to impaired renal function.<h4>Results</h4>In total, 163 patients were included, of whom 105 (64%) had received β-lactam antibiotics for a mean total duration of 13.0 months. There was a significant increase in the urine albu ...[more]
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