The expression of NLK is functionally associated with colorectal cancers (CRC).
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ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC8558666 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
The expression of NLK is functionally associated with colorectal cancers (CRC).
Chen Xinyan X Zhou Yifan Y Wan Yufeng Y Chen Tingting T Zhu Huaqing H Cheng Xiaowen X
Journal of Cancer 20211017 23
The regulatory mechanism of NLK in the carcinomagenesis and progression of colorectal cancer (CRC) remains unclear. Here, we identified a single nucleotide polymorphism (SNP) site of NLK (rs2125846) as a new susceptibility locus for CRC risk located within an intron of the human NLK gene in a Chinese population. NLK downregulation led to a decrease in the ability of proliferation and migration of RKO cells <i>in vitro</i>. The proportion of RKO apoptotic cells increased by interfering with the e ...[more]
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