Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice.

ABSTRACT: The liver has recently been identified as a major organ for destruction of desialylated platelets. However, the underlying mechanism remains unclear. Kupffer cells, which are professional phagocytic cells in the liver, comprise the largest population of resident tissue macrophages in the body. Kupffer cells express a C-type lectin receptor, CLEC4F, that recognizes desialylated glycans with an unclear in vivo role in mediating platelet destruction. In this study, we generated a CLEC4F-deficient mouse model (Clec4f^-/-) and found that CLEC4F was specifically expressed by Kupffer cells. Using the Clec4f^-/- mice and a newly generated platelet-specific reporter mouse line, we revealed a critical role for CLEC4F on Kupffer cells in mediating destruction of desialylated plate

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC8564511 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature