Dataset Information

Self-Therapeutic Cobalt Hydroxide Nanosheets (Co(OH)₂ NS) for Ovarian Cancer Therapy.

ABSTRACT: High-grade serous ovarian cancer (HGSOC) is one of the major life-threatening cancers in women, with a survival rate of less than 50%. So far, chemotherapy is the main therapeutic tool to cure this lethal disease; however, in many cases, it fails to cure HGSOC even with severe side effects. Self-therapeutic nanomaterials could be an effective alternative to chemotherapy, facilitated by their diverse physicochemical properties and the ability to generate reactive species for killing cancer cells. Herein, inorganic cobalt hydroxide nanosheets (Co(OH)₂ NS) were synthesized by a simple solution process at room temperature, and morphological, spectroscopic, and crystallographic analyses revealed the formation of Co(OH)₂ NS with good crystallinity and purity. The as-prepared Co(OH)₂ NS showed excellent potency, comparable to the FDA-approved cisplatin drug to kill ovarian cancer cells. Flow cytometric analysis (nnexin V) revealed increased cellular apoptosis for Co(OH)₂ NS than cobalt acetate (the precursor). Tracking experiments demonstrated that Co(OH)₂ NS are internalized through the lysosome pathway, although relocalization in the cytoplasm has been observed. Hence, Co(OH)₂ NS could be an effective self-therapeutic drug and open up an area for the optimization of self-therapeutic properties of cobalt nanomaterials for cancer treatment.

SUBMITTER: Adeel M

PROVIDER: S-EPMC8567285 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Self-Therapeutic Cobalt Hydroxide Nanosheets (Co(OH)<sub>2</sub> NS) for Ovarian Cancer Therapy.

Adeel Muhammad M Parisi Salvatore S Mauceri Matteo M Asif Kanwal K Bartoletti Michele M Puglisi Fabio F Caligiuri Isabella I Rahman Md Mahbubur MM Canzonieri Vincenzo V Rizzolio Flavio F

ACS omega 20211019 43

High-grade serous ovarian cancer (HGSOC) is one of the major life-threatening cancers in women, with a survival rate of less than 50%. So far, chemotherapy is the main therapeutic tool to cure this lethal disease; however, in many cases, it fails to cure HGSOC even with severe side effects. Self-therapeutic nanomaterials could be an effective alternative to chemotherapy, facilitated by their diverse physicochemical properties and the ability to generate reactive species for killing cancer cells. ...[more]

PMID: 34746556

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Project description:The cobalt carbonate hydroxide Co2CO3(OH)2 is a technologically important solid which is used as a precursor for the synthesis of cobalt oxides in a wide range of applications. It also has relevance as a potential immobilizer of the toxic element cobalt in the natural environment, but its detailed crystal structure is so far unknown. The structure of Co2CO3(OH)2 has now been investigated using density functional theory (DFT) simulations and powder X-ray diffraction (PXRD) measurements on samples synthesized via deposition from aqueous solution. Two possible monoclinic phases are considered, with closely related but symmetrically different crystal structures, based on those of the minerals malachite [Cu2CO3(OH)2] and rosasite [Cu1.5Zn0.5CO3(OH)2], as well as an orthorhombic phase that can be seen as a common parent structure for the two monoclinic phases, and a triclinic phase with the structure of the mineral kolwezite [Cu1.34Co0.66CO3(OH)2]. The DFT simulations predict that the rosasite-like and malachite-like phases are two different local minima of the potential energy landscape for Co2CO3(OH)2 and are practically degenerate in energy, while the orthorhombic and triclinic structures are unstable and experience barrierless transformations to the malachite phase upon relaxation. The best fit to the PXRD data is obtained using a rosasite model [monoclinic with space group P1121/n and cell parameters a = 3.1408 (4) Å, b = 12.2914 (17) Å, c = 9.3311 (16) Å and γ = 82.299 (16)°]. However, some features of the PXRD pattern are still not well accounted for by this refinement and the residual parameters are relatively poor. The relationship between the rosasite and malachite phases of Co2CO3(OH)2 is discussed and it is shown that they can be seen as polytypes. Based on the similar calculated stabilities of these two polytypes, it is speculated that some level of stacking disorder could account for the poor fit of the PXRD data. The possibility that Co2CO3(OH)2 could crystallize, under different growth conditions, as either rosasite or malachite, or even as a stacking-disordered phase intermediate between the two, requires further investigation.

Dataset Information

Self-Therapeutic Cobalt Hydroxide Nanosheets (Co(OH)₂ NS) for Ovarian Cancer Therapy.

Publications

Self-Therapeutic Cobalt Hydroxide Nanosheets (Co(OH)<sub>2</sub> NS) for Ovarian Cancer Therapy.

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Dataset Information

Self-Therapeutic Cobalt Hydroxide Nanosheets (Co(OH)2 NS) for Ovarian Cancer Therapy.

Publications

Self-Therapeutic Cobalt Hydroxide Nanosheets (Co(OH)<sub>2</sub> NS) for Ovarian Cancer Therapy.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Self-Therapeutic Cobalt Hydroxide Nanosheets (Co(OH)₂ NS) for Ovarian Cancer Therapy.