Hypofractionated radiotherapy for newly diagnosed elderly glioblastoma patients: A systematic review and network meta-analysis.

ABSTRACT:

Objective

To evaluate different hypofractionated radiotherapy (HRT) regimens for newly diagnosed elderly glioblastoma (GBM) patients.

Methods

We performed a systematic review with network meta-analysis (NMA), including searches on CENTRAL, Medline, EMBASE, CINAHL, clinical trial databases and manual search. Only randomized clinical trials (RCTs) were included. Primary outcomes: overall survival (OS) and adverse events (AE). Secondary outcomes: progression-free-survival (PFS) and quality of life (QoL). We used the Cochrane Risk of Bias (RoB) table for assessing individual studies and CINeMA for evaluating the certainty of the final body of evidence.

Results

Four RCTs (499 patients) were included. For OS, the estimates from NMA did not provide strong evidence of a diffe

SUBMITTER: Melo SM 

PROVIDER: S-EPMC8568110 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature