Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity.

ABSTRACT:

Importance

A comprehensive understanding of the benefits of COVID-19 vaccination requires consideration of disease attenuation, determined as whether people who develop COVID-19 despite vaccination have lower disease severity than unvaccinated people.

Objective

To evaluate the association between vaccination with mRNA COVID-19 vaccines-mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech)-and COVID-19 hospitalization, and, among patients hospitalized with COVID-19, the association with progression to critical disease.

Design, setting, and participants

A US 21-site case-control analysis of 4513 adults hospitalized between March 11 and August 15, 2021, with 28-day outcome data on death and mechanical ventilation available for patients enrolled through July 14, 2021. Date o

SUBMITTER: Tenforde MW 

PROVIDER: S-EPMC8569602 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature