CD248 enhances tissue factor procoagulant function, promoting arterial and venous thrombosis in mouse models.

ABSTRACT:

Background

CD248 is a pro-inflammatory, transmembrane glycoprotein expressed by vascular smooth muscle cells (VSMC), monocytes/macrophages, and other cells of mesenchymal origin. Its distribution and properties are reminiscent of those of the initiator of coagulation, tissue factor (TF).

Objective

We examined whether CD248 also participates in thrombosis.

Methods

We evaluated the role of CD248 in coagulation using mouse models of vascular injury, and by assessing its functional interaction with the TF-factor VIIa (FVIIa)-factor X (FX) complex.

Results

The time to ferric chloride-induced occlusion of the carotid artery in CD248 knockout (KO) mice was significantly longer than in wild-type (WT) mice. In an inferior vena cava (IVC) stenosis model of thrombosis, la

SUBMITTER: Kapopara PR 

PROVIDER: S-EPMC8571649 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature