The Organ Sparing Potential of Different Biological Optimization Strategies in Proton Therapy.

ABSTRACT:

Purpose

Variable relative biological effectiveness (RBE) models allow for differences in linear energy transfer (LET), physical dose, and tissue type to be accounted for when quantifying and optimizing the biological damage of protons. These models are complex and fraught with uncertainties, and therefore, simpler RBE optimization strategies have also been suggested. Our aim was to compare several biological optimization strategies for proton therapy by evaluating their performance in different clinical cases.

Methods and materials

Two different optimization strategies were compared: full variable RBE optimization and differential RBE optimization, which involve applying fixed RBE for the planning target volume (PTV) and variable RBE in organs at risk (OARs). The optimizatio

SUBMITTER: Henjum H 

PROVIDER: S-EPMC8573123 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature