Mitochondrial bioenergetics and D-ribose in HFpEF: a brief narrative review.

ABSTRACT:

Objective

In this review article, we briefly describe the status of treatment options for HFpEF and the role of mitochondrial dysfunction in the pathogenesis of HFpEF as an alternative therapeutic target. We also examine the mechanisms of D-ribose in cellular energy production and discuss the potential disadvantages and benefits of supplemental use of D-ribose in patients with HFpEF.

Background

Heart failure is a major cardiovascular disease that impacts over 6 million Americans and is one of the leading causes for morbidity and mortality. Patients with heart failure often experience shortness of breath and fatigue along with impaired physical capacity, all leading to poor quality of life. As a subtype of heart failure, heart failure with preserved ejection fraction (HFpEF)

SUBMITTER: Krueger KJ 

PROVIDER: S-EPMC8573443 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature