Dataset Information

Atractylenolide I inhibits antibiotic-induced dysbiosis of the intestinal microbiome.

ABSTRACT:

Background

Atractylenolide I (AT-I) is an active component that is isolated from Rhizoma Atractylodis macrocephalae and it exerts anti-apoptotic, anti-oxidant, and anti-coagulant properties, and has been widely applied in the treatment of cardiovascular and cerebrovascular diseases in China. This study aimed to investigate the effects and possible mechanism of AT-I on intestinal dysbacteriosis in a mouse model.

Methods

Mice dysbacteriosis models were established and treated with AT-I, and the intestinal microbiome of the mice were compared. Using antibiotics-induced bacterial elimination in an intestinal dysbacteriosis-associated xenograft model, the gut microbiota-mediated anti-tumor mechanism was investigated.

Results

The intestinal microbiome was changed in the dysbacteriosis mice compared to the control mice, and AT-I could affect the intestinal microbiome of the dysbacteriosis mice. Manipulation of gut bacteria in the intestines of the dysbacteriosis-associated xenograft model further confirmed that the inhibition of tumor progression by AT-I was mediated by the gut microbiota, and that the underlying mechanism involves down-regulation of TLR4/MyD88/NF-κB signaling. AT-I repressed the phosphorylation of p65-NF-κB as well as the downstream cytokines, IL-6 and IL-1β, in dysbacteriosis mice.

Conclusions

AT-I may inhibit dysbacteriosis by affecting the intestinal microbiome via the regulation of TLR4/MyD88/NF-κB signaling. The present study provides a basis for the application of AT-I as an alternative medication for treating gastrointestinal disorders.

SUBMITTER: Liu P

PROVIDER: S-EPMC8576645 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Atractylenolide I inhibits antibiotic-induced dysbiosis of the intestinal microbiome.

Liu Penglin P Zhao Gang G Zhang Lize L Gong Yuxia Y Gu Yunfei Y

Annals of translational medicine 20211001 20

<h4>Background</h4>Atractylenolide I (AT-I) is an active component that is isolated from Rhizoma Atractylodis macrocephalae and it exerts anti-apoptotic, anti-oxidant, and anti-coagulant properties, and has been widely applied in the treatment of cardiovascular and cerebrovascular diseases in China. This study aimed to investigate the effects and possible mechanism of AT-I on intestinal dysbacteriosis in a mouse model.<h4>Methods</h4>Mice dysbacteriosis models were established and treated with A ...[more]

PMID: 34790745

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Dataset Information

Atractylenolide I inhibits antibiotic-induced dysbiosis of the intestinal microbiome.

Background

Methods

Results

Conclusions

Publications

Atractylenolide I inhibits antibiotic-induced dysbiosis of the intestinal microbiome.

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