Atractylenolide I inhibits antibiotic-induced dysbiosis of the intestinal microbiome.

ABSTRACT:

Background

Atractylenolide I (AT-I) is an active component that is isolated from Rhizoma Atractylodis macrocephalae and it exerts anti-apoptotic, anti-oxidant, and anti-coagulant properties, and has been widely applied in the treatment of cardiovascular and cerebrovascular diseases in China. This study aimed to investigate the effects and possible mechanism of AT-I on intestinal dysbacteriosis in a mouse model.

Methods

Mice dysbacteriosis models were established and treated with AT-I, and the intestinal microbiome of the mice were compared. Using antibiotics-induced bacterial elimination in an intestinal dysbacteriosis-associated xenograft model, the gut microbiota-mediated anti-tumor mechanism was investigated.

Results

The intestinal microbiome was changed in the dys

SUBMITTER: Liu P 

PROVIDER: S-EPMC8576645 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature