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A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair.

ABSTRACT: A novel herbal extract-loaded gel containing several biofunctional extracts, including green tea, Zingiber officinale Rosc, Phyllanthus emblica, and salicylic acid, was developed for acne vulgaris. These natural raw materials were blended with suitable dosages of gelatin and carboxymethyl cellulose (CMC) to produce a biocompatible herbal gel. The physical chemistry properties of the hydrogel were determined by Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), rheometry, and scanning electron microscopy (SEM), and the hydrogel showed good mechanical and morphological characteristics. The herbal extract-loaded hydrogel mimicked extracellular matrix properties and showed good antioxidant and anti-inflammatory properties and various advantages, serving as a potential wound dressing material because of its high moisture retention ability, wound exudate absorption behavior, and biocompatibility. It exhibited moderate-high antioxidative and anti-inflammatory qualities that were important for dermis wound closure. The clinical trial results showed that most patients experienced moderate to high healing rates, and four of twenty-four individuals (16.67%) had recovery area ratios greater than 80%. This herbal extract-loaded hydrogel has effective ingredients and excellent mechanical properties as a bioactive dressing agent for acne treatment.

SUBMITTER: Lin YY

PROVIDER: S-EPMC8577930 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair.

Lin Ying-Yi YY Lu Shu-Hsu SH Gao Rong R Kuo Chia-Hung CH Chung Wen-Hisn WH Lien Wei-Chih WC Wu Ching-Chou CC Diao Yong Y Wang Hui-Min David HD

Oxidative medicine and cellular longevity 20211102

A novel herbal extract-loaded gel containing several biofunctional extracts, including green tea, <i>Zingiber officinale</i> Rosc, <i>Phyllanthus emblica</i>, and salicylic acid, was developed for acne vulgaris. These natural raw materials were blended with suitable dosages of gelatin and carboxymethyl cellulose (CMC) to produce a biocompatible herbal gel. The physical chemistry properties of the hydrogel were determined by Fourier transform infrared spectroscopy (FTIR), thermal gravimetric anal ...[more]

PMID: 34765083

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Dataset Information

A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair.

Publications

A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair.

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