Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10^-/- Mice.

ABSTRACT:

Background & aims

Perturbations in the early-life gut microbiome are associated with increased risk for complex immune disorders like inflammatory bowel diseases. We previously showed that maternal antibiotic-induced gut dysbiosis vertically transmitted to offspring increases experimental colitis risk in interleukin (IL) 10 gene deficient (IL10^-/-) mice, a finding that may result from the loss/lack of essential microbes needed for appropriate immunologic education early in life. Here, we aimed to identify key microbes required for proper development of the early-life gut microbiome that decrease colitis risk in genetically susceptible animals.

Methods

Metagenomic sequencing followed by reconstruction of metagenome-assembled genomes was performed on fecal samples o

SUBMITTER: Miyoshi J 

PROVIDER: S-EPMC8577987 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature