GPR120 Inhibits Colitis Through Regulation of CD4⁺ T Cell Interleukin 10 Production.

ABSTRACT:

Background & aims

G protein-coupled receptor (GPR) 120 has been implicated in regulating metabolic syndromes with anti-inflammatory function. However, the role of GPR120 in intestinal inflammation is unknown. Here, we investigated whether and how GPR120 regulates CD4⁺ T cell function to inhibit colitis development.

Methods

Dextran sodium sulfate (DSS)-induced colitis model, Citrobacter rodentium infection model, and CD4⁺ T cell adoptive transfer model were used to analyze the role of GPR120 in regulating colitis development. The effect of GPR120 on CD4⁺ T cell functions was analyzed by RNA sequencing, flow cytometry, and Seahorse metabolic assays. Mice were administered GPR120 agonist for investigating the potential of GPR120 agonist in preve

SUBMITTER: Yang W 

PROVIDER: S-EPMC8678294 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature