Dataset Information

Evaluation of inter- and intra-operator reliability of manual segmentation of femoral metastatic lesions.

ABSTRACT:

Purpose

Accurate identification of metastatic lesions is important for improvement in biomechanical models that calculate the fracture risk of metastatic bones. The aim of this study was therefore to assess the inter- and intra-operator reliability of manual segmentation of femoral metastatic lesions.

Methods

CT scans of 54 metastatic femurs (19 osteolytic, 17 osteoblastic, and 18 mixed) were segmented two times by two operators. Dice coefficients (DCs) were calculated adopting the quantification that a DC˃0.7 indicates good reliability.

Results

Generally, rather poor inter- and intra-operator reliability of lesion segmentation were found. Inter-operator DCs were 0.54 (± 0.28) and 0.50 (± 0.32) for the first and second segmentations, respectively, whereas intra-operator DCs were 0.56 (± 0.28) for operator I and 0.71 (± 0.23) for operator II. Larger lesions scored significantly higher DCs in comparison with smaller lesions. Of the femurs with larger mean segmentation volumes, 83% and 93% were segmented with good inter- and intra-operator DCs (> 0.7), respectively. There was no difference between the mean DCs of osteolytic, osteoblastic, and mixed lesions.

Conclusion

Manual segmentation of femoral bone metastases is very challenging and resulted in unsatisfactory mean reliability values. There is a need for development of a segmentation protocol to reduce the inter- and intra-operator segmentation variation as the first step and use of computer-assisted segmentation tools as a second step as this study shows that manual segmentation of femoral metastatic lesions is highly challenging.

SUBMITTER: Ataei A

PROVIDER: S-EPMC8580934 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Evaluation of inter- and intra-operator reliability of manual segmentation of femoral metastatic lesions.

Ataei Ali A Eggermont Florieke F Baars Milan M van der Linden Yvette Y de Rooy Jacky J Verdonschot Nico N Tanck Esther E

International journal of computer assisted radiology and surgery 20210715 10

<h4>Purpose</h4>Accurate identification of metastatic lesions is important for improvement in biomechanical models that calculate the fracture risk of metastatic bones. The aim of this study was therefore to assess the inter- and intra-operator reliability of manual segmentation of femoral metastatic lesions.<h4>Methods</h4>CT scans of 54 metastatic femurs (19 osteolytic, 17 osteoblastic, and 18 mixed) were segmented two times by two operators. Dice coefficients (DCs) were calculated adopting th ...[more]

PMID: 34268665

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Dataset Information

Evaluation of inter- and intra-operator reliability of manual segmentation of femoral metastatic lesions.

Purpose

Methods

Results

Conclusion

Publications

Evaluation of inter- and intra-operator reliability of manual segmentation of femoral metastatic lesions.

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