Polyamine metabolism links gut microbiota and testicular dysfunction.

ABSTRACT:

Background

Male fertility impaired by exogenous toxins is a serious worldwide issue threatening the health of the new-born and causing infertility. However, the metabolic connection between toxic exposures and testicular dysfunction remains unclear.

Results

In the present study, the metabolic disorder of testicular dysfunction was investigated using triptolide-induced testicular injury in mice. We found that triptolide induced spermine deficiency resulting from disruption of polyamine biosynthesis and uptake in testis, and perturbation of the gut microbiota. Supplementation with exogenous spermine reversed triptolide-induced testicular dysfunction through increasing the expression of genes related to early and late spermatogenic events, as well as increasing the reduced numb

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC8582214 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature