Divergent COVID-19 Disease Trajectories Predicted by a DAMP-Centered Immune Network Model.

ABSTRACT: COVID-19 presentations range from mild to moderate through severe disease but also manifest with persistent illness or viral recrudescence. We hypothesized that the spectrum of COVID-19 disease manifestations was a consequence of SARS-CoV-2-mediated delay in the pathogen-associated molecular pattern (PAMP) response, including dampened type I interferon signaling, thereby shifting the balance of the immune response to be dominated by damage-associated molecular pattern (DAMP) signaling. To test the hypothesis, we constructed a parsimonious mechanistic mathematical model. After calibration of the model for initial viral load and then by varying a few key parameters, we show that the core model generates four distinct viral load, immune response and associated disease trajectories termed "pat

SUBMITTER: Day JD 

PROVIDER: S-EPMC8582279 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature