Identification for antitumor effects of tramadol in a xenograft mouse model using orthotopic breast cancer cells.

ABSTRACT: In our previous research showed that tramadol having potential anti-tumor effect was associated with enhancement of oncological prognosis in patients with breast cancer surgery. As these effects have not been confirmed by clinical dose-regulated animal or prospective human studies, we investigated the anti-tumor effect of tramadol in vivo. Female nude mice orthotopically inoculated with luciferase-expressing MCF-7 cells, were randomly divided into the control (saline), tramadol group 1 (1.5 mg kg^-1 day^-1), tramadol group 2 (3 mg kg^-1 day^-1), and morphine (0.5 mg kg^-1 day^-1) (n = 5/group). Bioluminescence signals after D-luciferin injection, tumor size, and tumor weight were compared among groups after 4 weeks. Estrogen recep

SUBMITTER: Kim MH 

PROVIDER: S-EPMC8586351 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature