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Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer's Disease.

ABSTRACT: The pathogenesis of Alzheimer's disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, Ramalina terebrata), which exhibits various physiological activities, in AD. Specifically, derivatives were synthesized based on the structure of ramalin, which has a strong antioxidant effect, BACE-1 inhibition activity, and anti-inflammatory effects. Therefore, ramalin and its derivatives exhibit activity against multiple targets associated with AD and can serve as potential therapeutic agents for the disease.

SUBMITTER: Kim TK

PROVIDER: S-EPMC8588271 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer's Disease.

Kim Tai Kyoung TK Hong Ju-Mi JM Kim Kyung Hee KH Han Se Jong SJ Kim Il-Chan IC Oh Hyuncheol H Yim Joung Han JH

Molecules (Basel, Switzerland) 20211026 21

The pathogenesis of Alzheimer's disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, <i>Ramalina terebrata</i>), which exhibits various physiological activities, in AD. Specifically, derivatives were synthesized based on the structure of ramalin, which has a strong antioxidant effect, BACE-1 inhibition activity, an ...[more]

PMID: 34770857

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