Moderate Physical Exercise Activates ATR₂ Receptors, Improving Inflammation and Oxidative Stress in the Duodenum of 2K1C Hypertensive Rats.

ABSTRACT: Background: In addition to the cardiovascular and renal systems, the gastrointestinal tract also contains angiotensin ATR_1a, ATR_1b, and ATR₂. We previously observed that the 2Kidney-1Clip hypertension model elicits physical exercise and gastrointestinal dysmotility, which is prevented by renin-angiotensin system blockers. Here, we investigate the effect of physical exercise on inflammation, stress biomarkers, and angiotensin II receptors in the duodenum of 2K1C rats. Methods: Arterial hypertension was induced by the 2K1C surgical model. The rats were allocated in Sham, 2K1C, or 2K1C+Exercise groups. One week after surgery, they were submitted to a physical exercise protocol (running 5x/week, 60min/day). Next, we assessed their intestinal contr

SUBMITTER: da Silva ACA 

PROVIDER: S-EPMC8588860 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature