Progress in Treating Advanced Thyroid Cancers in the Era of Targeted Therapy.

ABSTRACT: Background: Thyroid cancer is a common malignancy whose detection has increased significantly in past decades. Most of the increased incidence is due to detection of early well-differentiated thyroid cancer, but the incidence of more advanced thyroid cancers has increased as well. Recent methodological advancements have allowed for a deep understanding of the molecular underpinnings of the various types of thyroid cancer. Summary: Thyroid cancers harbor a high frequency of potential druggable molecular alterations, including the highest frequency of oncogenic driver kinase fusions seen across all solid tumors. Analyses of poorly differentiated and anaplastic thyroid carcinoma confirmed that these tumors develop from more well-differentiated follicular-derived th

SUBMITTER: Lubitz CC 

PROVIDER: S-EPMC8591086 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature