α-galactosylceramide-stimulated invariant natural killer T-cells play a protective role in murine vulvovaginal candidiasis by Candida albicans.

ABSTRACT:

Background

Vulvovaginal candidiasis is a common superficial candidiasis; however, a host's immunological mechanism against vaginal Candida infection remains unknown.

Objectives

In this study, we aimed to elucidate the effect of iNKT cell activation on vulvovaginal candidiasis.

Methods

Using a vulvovaginal candidiasis model with estrogenized mice, we evaluated the fungal burden and number of leukocyte infiltrations in the vaginal lavage of wild-type C57BL/6J mice after Candida albicans inoculation. One day before C. albicans inoculation, α-galactosylceramide (the α-GalCer group) or sterile phosphate-buffered saline (the sham group) was intraperitoneally injected into the mice. We also evaluated the level of antimicrobial peptide S100A8 in the vaginal lavage and analyze

SUBMITTER: Abe M 

PROVIDER: S-EPMC8594805 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature