Ontology highlight
ABSTRACT:
SUBMITTER: Sun X
PROVIDER: S-EPMC8596119 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Sun Xiaoyan X Xiang Jiangbing J Chen Runkai R Geng Zhijun Z Wang Lintao L Liu Yiqiong Y Ji Shuaifei S Chen Huating H Li Yan Y Zhang Cuiping C Liu Peng P Yue Tao T Dong Lei L Fu Xiaobing X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20210926 22
Restoration of sweat glands (SwGs) represents a great issue in patients with extensive skin defects. Recent methods combining organoid technology with cell fate reprogramming hold promise for developing new regenerative methods for SwG regeneration. Here, a practical strategy for engineering functional human SwGs in vitro and in vivo is provided. First, by forced expression of the ectodysplasin-A in human epidermal keratinocytes (HEKs) combined with specific SwG culture medium, HEKs are efficien ...[more]