Limited Flavivirus Cross-Reactive Antibody Responses Elicited by a Zika Virus Deoxyribonucleic Acid Vaccine Candidate in Humans.
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ABSTRACT:
SUBMITTER: Burgomaster KE
PROVIDER: S-EPMC8599923 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Limited Flavivirus Cross-Reactive Antibody Responses Elicited by a Zika Virus Deoxyribonucleic Acid Vaccine Candidate in Humans.
Burgomaster Katherine E KE Foreman Bryant M BM Aleshnick Maya A MA Larman Bridget C BC Gordon David N DN Maciejewski Sonia S Morabito Kaitlyn M KM Ledgerwood Julie E JE Gaudinski Martin R MR Chen Grace L GL Mascola John R JR Debbink Kari K Dowd Kimberly A KA Graham Barney S BS Pierson Theodore C TC
The Journal of infectious diseases 20211101 9
Zika virus (ZIKV) deoxyribonucleic acid vaccine VRC5283 encoding viral structural genes has been shown to be immunogenic in humans. Recognizing that antigenically related flaviviruses cocirculate in regions with ZIKV activity, we explored the degree of antibody cross-reactivity elicited by this vaccine candidate using genetically diverse flaviviruses. The antibody response of vaccinated individuals with no evidence of prior flavivirus infection or vaccine experience had a limited capacity to bin ...[more]
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