Association Between CLOCK Gene Variants and Restless Legs Syndrome in Koreans.

ABSTRACT:

Objective

Previous studies have suggested various causes of restless legs syndrome (RLS), including iron and dopamine concentrations in the brain. Genetic influences have also been reported in many studies. There is also a possibility that circadian clock genes may be involved because symptoms of RLS worsen at night. We investigated whether CLOCK and NPAS2 gene polymorphisms were associated with RLS.

Methods

A total of 227 patients with RLS and 229 non-RLS matched controls were assessed according to the International Restless Legs Syndrome Study Group diagnostic criteria. Genotyping was performed using reverse transcription polymerase chain reaction and high-resolution melting curve analyses.

Results

Although the genotype distributions of the CLOCK variants (rs1801260

SUBMITTER: Seo JE 

PROVIDER: S-EPMC8600210 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature