Glycosylation of PAMAM dendrimers significantly improves tumor macrophage targeting and specificity in glioblastoma.

ABSTRACT: Glioblastoma is among the most aggressive forms of cancers, with a median survival of just 15-20 months for patients despite maximum clinical intervention. The majority of conventional anti-cancer therapies fail due to associated off-site toxicities which can be addressed by developing target-specific drug delivery systems. Advances in nanotechnology have provided targeted systems to overcome drug delivery barriers associated with brain and other types of cancers. Dendrimers have emerged as promising vehicles for targeted drug and gene delivery. Dendrimer-mediated targeting strategies can be further enhanced through the addition of targeting ligands to enable receptor-specific interactions. Here, we explore the sugar moieties as ligands conjugated to hydroxyl-terminated polyamidoamine dend

SUBMITTER: Sharma R 

PROVIDER: S-EPMC8600682 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature