Transcriptomic response of zebrafish embryos to Polyamidoamine (PAMAM) dendrimers

ABSTRACT: We are presenting here the application of toxicogenomics to perform the evaluation of toxic effects of two polyamidoamine dendrimers (Generation3 and Generation4) on the developing zebrafish embryo. They are nanomaterials of special concern under the toxicological point of view because of their relatively high solubility in water and bioavailability. Zebrafish embryo toxicity assays (zFET) showed that G3 was more toxic to zebrafish than G4, and that both compounds were several orders of magnitude more toxic than other carbonaceous nanomaterials, like carbon fullerenes or nanotubes. The results suggest a variety of MoA for different dendrimers, probably related to the nature and number of the chemical groups attached to their surface. They also confirm the relatively high bioavailability of

ORGANISM(S): Danio rerio

SUBMITTER: Eva Oliveira 

PROVIDER: E-GEOD-41333 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress