Toxicogenomic analysis of rural and urban air particles

ABSTRACT: Atmospheric particulate matter (PM) is a recognized risk factor for the global burden of disease in human populations. We are presenting here the application of toxicogenomics in the evaluation of the toxic effects of organic content of atmospheric particle matter (PM), from urban and rural environments (city of Barcelona and village of La Pobla, NE Spain), using the developing zebrafish embryo. The main goal is to identify the metabolic pathways involved in the adverse effects observed in zebrafish embryos exposed to PM organic content from urban and rural environments, also allowing the selection of genes of interest that are differentially expressed. The relevance of particle size to the PM toxicity is also addressed. Indeed, the zebrafish embryos were exposed to PM of aerodynamic diame

ORGANISM(S): Danio rerio

SUBMITTER: Sofia Raquel Mesquita 

PROVIDER: E-GEOD-53522 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress