Gut microbiome functionality might be associated with exercise tolerance and recurrence of resected early-stage lung cancer patients.

ABSTRACT: Impaired exercise tolerance and lung function is a marker for increased mortality in lung cancer patients undergoing lung resection surgery. Recent data suggest that the gut-lung axis regulates systemic metabolic and immune functions, and microbiota might alter exercise tolerance. Here, we aimed to evaluate the associations between gut microbiota and outcomes in lung cancer patients who underwent lung resection surgery. We analysed stool samples, from 15 early-stage lung cancer patients, collected before and after surgical resection using shotgun metagenomic and Internal Transcribed Spacer (ITS) sequencing. We analysed microbiome and mycobiome associations with post-surgery lung function and cardiopulmonary exercise testing (CPET) to assess the maximum level of work achieved. There was a s

SUBMITTER: Marfil-Sanchez A 

PROVIDER: S-EPMC8601557 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature