Dataset Information

Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI.

ABSTRACT:

Background

We assessed the 5-year risk of being diagnosed with significant prostate cancer following a low-suspicion biparametric magnetic resonance imaging result.

Methods

The study population was derived from a prospective database used to assess the diagnostic accuracy of biparametric magnetic resonance imaging for significant prostate cancer detection in 1020 biopsy-naïve men. Significant prostate cancer was defined as any core with Gleason grade group ≥3 or a maximum cancerous core length greater than 50% of Gleason grade group 2. A secondary definition of significant prostate cancer was also included: any core with prostate cancer Gleason grade group ≥2. Of the 1020 men, 305 had a low-suspicion biparametric magnetic resonance imaging result (Prostate Imaging Reporting and Data System score of 1 or 2) but four men were excluded from follow-up. Thus, the final study population consisted of 301 men, who were clinically followed-up from inclusion (November 2015 to June 2017) until 1 June 2021.

Findings

Overall, 1·7% (5/301) of the study population had significant prostate cancer diagnosed within 5 years (median 1480 days, Interquartile Range (1587-1382)) of their low-suspicion result and corresponding set of biopsies. When the secondary definition of significant prostate cancer was applied, this increased to 5% (15/301) of the study population.

Interpretation

The 5-year risk of being diagnosed with significant prostate cancer after a prebiopsy low-suspicion prebiopsy biparametric magnetic resonance imaging result was 1·7%.

SUBMITTER: Kortenbach KC

PROVIDER: S-EPMC8601994 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Publications

Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI.

Kortenbach Karen-Cecilie KC Boesen Lars L Løgager Vibeke V Thomsen Henrik S HS

Heliyon 20211106 11

<h4>Background</h4>We assessed the 5-year risk of being diagnosed with significant prostate cancer following a low-suspicion biparametric magnetic resonance imaging result.<h4>Methods</h4>The study population was derived from a prospective database used to assess the diagnostic accuracy of biparametric magnetic resonance imaging for significant prostate cancer detection in 1020 biopsy-naïve men. Significant prostate cancer was defined as any core with Gleason grade group ≥3 or a maximum cancerou ...[more]

PMID: 34820539

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Project description:BackgroundRadiomics or computer-extracted texture features derived from MRI have been shown to help quantitatively characterize prostate cancer (PCa). Radiomics have not been explored depth in the context of predicting biochemical recurrence (BCR) of PCa.PurposeTo identify a set of radiomic features derived from pretreatment biparametric MRI (bpMRI) that may be predictive of PCa BCR.Study typeRetrospective.SubjectsIn all, 120 PCa patients from two institutions, I1 and I2 , partitioned into training set D1 (N = 70) from I1 and independent validation set D2 (N = 50) from I2 . All patients were followed for ≥3 years.Sequence3T, T2 -weighted (T2 WI) and apparent diffusion coefficient (ADC) maps derived from diffusion-weighted sequences.AssessmentPCa regions of interest (ROIs) on T2 WI were annotated by two experienced radiologists. Radiomic features from bpMRI (T2 WI and ADC maps) were extracted from the ROIs. A machine-learning classifier (CBCR ) was trained with the best discriminating set of radiomic features to predict BCR (pBCR ).Statistical testsWilcoxon rank-sum tests with P < 0.05 were considered statistically significant. Differences in BCR-free survival at 3 years using pBCR was assessed using the Kaplan-Meier method and compared with Gleason Score (GS), PSA, and PIRADS-v2.ResultsDistribution statistics of co-occurrence of local anisotropic gradient orientation (CoLlAGe) and Haralick features from T2 WI and ADC were associated with BCR (P < 0.05) on D1 . CBCR predictions resulted in a mean AUC = 0.84 on D1 and AUC = 0.73 on D2 . A significant difference in BCR-free survival between the predicted classes (BCR + and BCR-) was observed (P = 0.02) on D2 compared to those obtained from GS (P = 0.8), PSA (P = 0.93) and PIRADS-v2 (P = 0.23).Data conclusionRadiomic features from pretreatment bpMRI can be predictive of PCa BCR after therapy and may help identify men who would benefit from adjuvant therapy.Level of evidence4 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2018;48:1626-1636.

Dataset Information

Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI.

Background

Methods

Findings

Interpretation

Publications

Outcome of 5-year follow-up in men with negative findings on initial biparametric MRI.

Similar Datasets

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