Systematic analysis of the lysine malonylome in Sanghuangporus sanghuang.

ABSTRACT:

Background

Sanghuangporus sanghuang is a well-known traditional medicinal mushroom associated with mulberry. Despite the properties of this mushroom being known for many years, the regulatory mechanisms of bioactive compound biosynthesis in this medicinal mushroom are still unclear. Lysine malonylation is a posttranslational modification that has many critical functions in various aspects of cell metabolism. However, at present we do not know its role in S. sanghuang. In this study, a global investigation of the lysine malonylome in S. sanghuang was therefore carried out.

Results

In total, 714 malonyl modification sites were matched to 255 different proteins. The analysis indicated that malonyl modifications were involved in a wide range of cellular functions and displayed a

SUBMITTER: Wang T 

PROVIDER: S-EPMC8603570 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature