Macrophage-biomimetic porous Se@SiO₂ nanocomposites for dual modal immunotherapy against inflammatory osteolysis.

ABSTRACT:

Background

Inflammatory osteolysis, a major complication of total joint replacement surgery, can cause prosthesis failure and necessitate revision surgery. Macrophages are key effector immune cells in inflammatory responses, but excessive M1-polarization of dysfunctional macrophages leads to the secretion of proinflammatory cytokines and severe loss of bone tissue. Here, we report the development of macrophage-biomimetic porous SiO₂-coated ultrasmall Se particles (porous Se@SiO₂ nanospheres) to manage inflammatory osteolysis.

Results

Macrophage membrane-coated porous Se@SiO₂ nanospheres(M-Se@SiO₂) attenuated lipopolysaccharide (LPS)-induced inflammatory osteolysis via a dual-immunomodulatory effect. As macrophage membrane decoys, t

SUBMITTER: Ding C 

PROVIDER: S-EPMC8607681 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature