Avobenzone incorporation in a diverse range of Ru(II) scaffolds produces potent potential antineoplastic agents.

ABSTRACT: Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy.

SUBMITTER: Ryan RT 

PROVIDER: S-EPMC8607750 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature