Avobenzone incorporation in a diverse range of Ru(II) scaffolds produces potent potential antineoplastic agents.
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ABSTRACT:
SUBMITTER: Ryan RT
PROVIDER: S-EPMC8607750 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Avobenzone incorporation in a diverse range of Ru(II) scaffolds produces potent potential antineoplastic agents.
Ryan Raphael T RT Havrylyuk Dmytro D Stevens Kimberly C KC Moore L Henry LH Kim Doo Young DY Blackburn Jessica S JS Heidary David K DK Selegue John P JP Glazer Edith C EC
Dalton transactions (Cambridge, England : 2003) 20200901 35
Four structurally distinct classes of polypyridyl ruthenium complexes containing avobenzone exhibited low micromolar and submicromolar potencies in cancer cells, and were up to 273-fold more active than the parent ligand. Visible light irradiation enhanced the cytotoxicity of some complexes, making them promising candidates for combined chemo-photodynamic therapy. ...[more]
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