Effectiveness of Implantable Cardioverter-Defibrillators to Reduce Mortality in Patients With Long QT Syndrome.

ABSTRACT:

Background

The effectiveness of implantable cardioverter-defibrillators (ICDs) on reducing mortality has not been well studied in patients with long QT syndrome (LQTS).

Objectives

This study aimed to assess the survival benefits of ICDs in the overall LQTS population and in subgroups defined by ICD indications.

Methods

This study included 3,035 patients (597 with ICD) from the Rochester LQTS Registry with a QTc ≥470 milliseconds or confirmed LQTS mutation. Using multivariable Cox proportional hazards models, the risk of all-cause mortality, all-cause mortality before age 50 years, and sudden cardiac death (SCD) were estimated as functions of time-dependent ICD therapy. Indication subgroups examined included patients with: 1) nonfatal cardiac arrest; 2) syncope while o

SUBMITTER: Wang M 

PROVIDER: S-EPMC8608269 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature