Modeling hepatitis C virus kinetics during liver transplantation reveals the role of the liver in virus clearance.

ABSTRACT: While the liver, specifically hepatocytes, are widely accepted as the main source of hepatitis C virus (HCV) production, the role of the liver/hepatocytes in clearance of circulating HCV remains unknown. Frequent HCV kinetic data were recorded and mathematically modeled from five liver transplant patients throughout the anhepatic (absence of liver) phase and for 4 hr post-reperfusion. During the anhepatic phase, HCV remained at pre-anhepatic levels (n = 3) or declined (n = 2) with t_1/2~1 hr. Immediately post-reperfusion, virus declined in a biphasic manner in four patients consisting of a rapid decline (t_1/2 = 5 min) followed by a slower decline (t_1/2 = 67 min). Consistent with the majority of patients in the anhepatic pha

SUBMITTER: Shekhtman L 

PROVIDER: S-EPMC8608386 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature