Ontology highlight
ABSTRACT:
SUBMITTER: Lai HE
PROVIDER: S-EPMC8609527 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
ACS chemical biology 20211014 11
Natural products and their analogues are often challenging to synthesize due to their complex scaffolds and embedded functional groups. Solely relying on engineering the biosynthesis of natural products may lead to limited compound diversity. Integrating synthetic biology with synthetic chemistry allows rapid access to much more diverse portfolios of xenobiotic compounds, which may accelerate the discovery of new therapeutics. As a proof-of-concept, by supplementing an <i>Escherichia coli</i> st ...[more]