Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology.

ABSTRACT:

Objective

The aim of this study was to determine the effect of dietary weight loss on neuropathy outcomes in people with severe obesity.

Methods

A prospective cohort study of participants attending a medical weight-management program was followed. Weight loss was achieved with meal replacement of 800 kcal/d for 12 weeks and then transitioning to 1,200 to 1,500 kcal/d. The coprimary outcomes were changes in intraepidermal nerve fiber density (IENFD) at the distal leg and proximal thigh. Secondary outcomes included nerve conduction studies, Michigan Neuropathy Screening Instrument questionnaire and exam, Quality of Life in Neurological Disorders, and quantitative sensory testing.

Results

Among 131 baseline participants, 72 (mean [SD] age: 50.1 [10.5] years, 51.4% female

SUBMITTER: Callaghan BC 

PROVIDER: S-EPMC8612943 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature