Ontology highlight
ABSTRACT:
SUBMITTER: Paglia G
PROVIDER: S-EPMC8614999 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Paglia Giuliano G Antonini Lorenzo L Cervoni Laura L Ragno Rino R Sabatino Manuela M Minacori Marco M Rubini Elisabetta E Altieri Fabio F
Biomedicines 20211025 11
In a previous work, it was shown that punicalagin, an active ingredient of pomegranate, is able to bind to PDIA3 and inhibit its disulfide reductase activity. Here we provide evidence that punicalagin can also bind to PDIA1, the main expressed form of protein disulfide isomerase (PDI). In this comparative study, the affinity and the effect of punicalagin binding on each protein were evaluated, and a computational approach was used to identify putative binding sites. Punicalagin binds to either P ...[more]