Genomic Characterization of a Proteus sp. Strain of Animal Origin Co-Carrying bla_NDM-1 and lnu(G).

ABSTRACT: The emergence of carbapenem-resistant Proteus represents a serious threat to global public health due to limited antibiotic treatment options. Here, we characterize a Proteus isolate NMG38-2 of swine origin that exhibits extensive drug resistance, including carbapenems. Whole-genome sequencing based on Illumina and MinION platforms showed that NMG38-2 contains 24 acquired antibiotic resistance genes and three plasmids, among which, pNDM_NMG38-2, a pPvSC3-like plasmid, is transferable and co-carries bla_NDM-1 and lnu(G). Sequence analysis of pPvSC3-like plasmids showed that they share a conserved backbone but have a diverse accessory module with complex chimera structures bearing abundant resistance genes, which are facilitated by transposons and/or hom

SUBMITTER: Li Y 

PROVIDER: S-EPMC8615141 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature