Sex-specific adaptations to high-salt diet preserve electrolyte homeostasis with distinct sodium transporter profiles.

ABSTRACT: Kidneys continuously filter an enormous amount of sodium and adapt kidney Na⁺ reabsorption to match Na⁺ intake to maintain circulatory volume and electrolyte homeostasis. Males (M) respond to high-salt (HS) diet by translocating proximal tubule Na⁺/H⁺ exchanger isoform 3 (NHE3) to the base of the microvilli, reducing activated forms of the distal NaCl cotransporter (NCC) and epithelial Na⁺ channel (ENaC). Males (M) and females (F) on normal-salt (NS) diet present sex-specific profiles of "transporters" (cotransporters, channels, pumps, and claudins) along the nephron, e.g., F exhibit 40% lower NHE3 and 200% higher NCC abundance than M. We tested the hypothesis that adaptations to HS diet along the nephron will, likewise, exhibit sexual

SUBMITTER: Torres-Pinzon DL 

PROVIDER: S-EPMC8616593 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature