Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals.

ABSTRACT: Roughly 10% of the human population is left-handed, and this rate is increased in some brain-related disorders. The neuroanatomical correlates of hand preference have remained equivocal. We resampled structural brain image data from 28,802 right-handers and 3,062 left-handers (UK Biobank population dataset) to a symmetrical surface template, and mapped asymmetries for each of 8,681 vertices across the cerebral cortex in each individual. Left-handers compared to right-handers showed average differences of surface area asymmetry within the fusiform cortex, the anterior insula, the anterior middle cingulate cortex, and the precentral cortex. Meta-analyzed functional imaging data implicated these regions in executive functions and language. Polygenic disposition to left-handedness was associat

SUBMITTER: Sha Z 

PROVIDER: S-EPMC8617418 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature