PharmVIP: A Web-Based Tool for Pharmacogenomic Variant Analysis and Interpretation.

ABSTRACT: The increasing availability of next generation sequencing (NGS) for personal genomics could promote pharmacogenomics (PGx) discovery and application. However, current tools for analysis and interpretation of pharmacogenomic variants from NGS data are inadequate, as none offer comprehensive analytic functions in a simple, web-based platform. In addition, no tools exist to analyze human leukocyte antigen (HLA) genes for determining potential risks of immune-mediated adverse drug reaction (IM-ADR). We describe PharmVIP, a web-based PGx tool, for one-stop comprehensive analysis and interpretation of genome-wide variants obtained from NGS platforms. PharmVIP comprises three main interpretation modules covering analyses of pharmacogenes involved in pharmacokinetics, pharmacodynamics and IM-ADR.

SUBMITTER: Piriyapongsa J 

PROVIDER: S-EPMC8618518 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature