RETRACTED: Protection against Oxidative Stress-Induced Apoptosis by Fermented Sea Tangle (<i>Laminaria japonica</i> Aresch) in Osteoblastic MC3T3-E1 Cells through Activation of Nrf2 Signaling Pathway.

ABSTRACT: The purpose of the present study was to explore the efficacy of fermented extract of sea tangle (Laminaria japonica Aresch, FST) with Lactobacillus brevis on DNA damage and apoptosis in hydrogen peroxide (H₂O₂)-stimulated osteoblastic MC3T3-E1 cells and clarify related signaling pathways. Our results showed that exposure to FST significantly improved cell viability, inhibited apoptosis, and suppressed the generation of reactive oxygen species (ROS) in H₂O₂-stimulated cells. In addition, H₂O₂ triggered DNA damage in MC3T3-E1 cells was markedly attenuated by FST pretreatment. Moreover, H₂O₂-induced mitochondrial dysfunctions associated with apoptotic events, including loss of mitochondrial m

SUBMITTER: Kim SY 

PROVIDER: S-EPMC8623046 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature