Molecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development.

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease (ILD) of unknown aetiology, with a median survival of 2-4 years from the time of diagnosis. Although IPF has unknown aetiology by definition, there have been identified several risks factors increasing the probability of the onset and progression of the disease in IPF patients such as cigarette smoking and environmental risk factors associated with domestic and occupational exposure. Among them, cigarette smoking together with concomitant emphysema might predispose IPF patients to lung cancer (LC), mostly to non-small cell lung cancer (NSCLC), increasing the risk of lung cancer development. To this purpose, IPF and LC share several cellular and molecular processes driving the progression of b

SUBMITTER: Samarelli AV 

PROVIDER: S-EPMC8624248 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature