Antibacterial Meroterpenoids, Merochlorins G-J from the Marine Bacterium Streptomyces sp.

ABSTRACT: Four new chlorinated meroterpenoids, merochlorins G-J (1-4), and 10, a dihydronaphthalenedione precursor, along with known merochlorins A (5) and C-F (6-9), were obtained from cultivation of the bacterium strain Streptomyces sp. CNH-189, which was isolated from marine sediment. The planar structures of compounds 1-4 and 10 were elucidated by interpretation of MS, UV, and NMR spectroscopic data. The relative configurations of compounds 1-4 were determined via analysis of nuclear Overhauser effect (NOE) spectroscopic data, after which their absolute configurations were established by comparing the experimental electronic circular dichroism (ECD) spectra of compounds 1-4 to those of previously re

SUBMITTER: Ryu MJ 

PROVIDER: S-EPMC8624273 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature