Efficacy and safety of novel glycopeptides versus vancomycin for the treatment of gram-positive bacterial infections including methicillin resistant Staphylococcus aureus: A systematic review and meta-analysis.

ABSTRACT:

Objective

To compare between current evidence of novel glycopeptides against vancomycin for the treatment of gram-positive bacterial infections.

Methodology

A systematic review and meta-analysis was done. Major databases were searched for eligible randomized control trials that assessed clinical success, microbiological success and safety profile of novel glycopeptides versus vancomycin for infections caused by gram-positive bacteria.

Results

This meta-analysis included eleven trials (7289 participants) comparing telavancin, dalbavancin and oritavancin with vancomycin. No differences were detected between novel glycopeptides and vancomycin for the treatment of skin and soft tissue infections (SSTIs) among modified intent-to-treat patients (OR: 1.04, CI: 0.92-1.17) as

SUBMITTER: Jame W 

PROVIDER: S-EPMC8629313 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature