The role of the PPARG (Pro12Ala) common genetic variant on type 2 diabetes mellitus risk.

ABSTRACT:

Background

Type 2 diabetes (T2DM) prevalence has been rapidly increasing in the last decades. T2DM pathogenesis is related to insulin resistance and beta-cell dysfunction. Peroxisome proliferator-activated receptor gamma (PPARG) is concerned about T2DM risk through the involvement in adipocyte differentiation and energy homeostasis. The present study aimed to find the risk associated with a common genetic variant (Pro12Ala) of the PPARG gene in the development of T2DM in a group of the Iranian population.

Methods

Totally, 149 patients with T2DM and 96 healthy individuals were recruited in this case-control study. The genotyping of the genetic variant was carried out using the polymerase chain reaction (PCR) followed by Sanger sequencing.

Results

No signi

SUBMITTER: Hashemian L 

PROVIDER: S-EPMC8630345 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature