Identifying the Predictive Role of Oxidative Stress Genes in the Prognosis of Glioma Patients.

ABSTRACT: BACKGROUND Gliomas are primary aggressive brain tumors with poor prognoses. Oxidative stress plays a crucial role in the tumorigenesis and drug resistance of gliomas. The aim of the present study was to use integrated bioinformatics analyses to evaluate the prognostic value of oxidative stress-related genes (OSRGs) in glioma. MATERIAL AND METHODS Disease- and prognosis-associated OSRGs were identified using microarray and clinical data from the Chinese Glioma Genome Atlas database. Functional enrichment, gene-gene interaction, protein-protein interaction, and survival analyses were performed in screened OSRGs. The protein expression was validated by the Human Protein Atlas database. A risk score model was constructed and verified through Cox regression, receiver operating characteristic cu

SUBMITTER: Lu D 

PROVIDER: S-EPMC8634738 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature